Certification Board of Infection Control and Epidemiology (CBIC) 2025 – 400 Free Practice Questions to Pass the Exam

Staphylococcus aureus is the organism that is most commonly associated with osteomyelitis, which is an infection of the bone. This is primarily because Staphylococcus aureus is a frequent pathogen found in skin and soft tissue infections, and it can easily spread to the bone, especially through open fractures or after surgical procedures.

Additionally, Staphylococcus aureus is capable of forming biofilms on the surface of implants and in the presence of foreign bodies, making it particularly difficult to eradicate in cases of osteomyelitis that arise from these conditions. While other organisms such as Klebsiella, Pseudomonas, and E. coli can cause osteomyelitis, they are less common and often associated with specific risk factors like diabetic foot infections or immunocompromised states. In general clinical practice, Staphylococcus aureus remains the most frequently isolated pathogen in cases of osteomyelitis, positioning it as the primary concern for healthcare providers tasked with diagnosing and treating this condition.